Genes and ConSEQUENCES Classroom Kit

• Use specific examples to explain central dogma
• Introduce students to the NCBI database and related tools
• Provide real-world examples of complex genetic interactions
• Use and interpret electropherogram diagrams
• Understand the role of protein products in diseases

In today's fast-paced world of genetics, a tremendous number of DNA sequences are being generated by scientists around the world. Unlocking the power of these sequences requires a specific skill set and a keen understanding of using databases and conducting sequence comparisons. Accessing the National Center for Biotechnology Information (NCBI) database, students use the Basic Local Alignment Search Tool (BLAST) to compare their sequences to gene segments published in the database. Using a case study approach, students continue to explore their sequences as they work to determine the location and role of their gene in a disease. Kit is designed to continually reinforce the central dogma of biology and give students basic knowledge of these database tools. Designed for 30 students working in pairs, the kit also includes 1-year access to digital resources that support 3-dimensional instruction.